Diisopropylethylamine → HCID 68682074, compound

HRID 1594344Notes

Reaction equation

HRID 1594344 reaction equation
Cl.[NH:2]1[CH2:7][CH2:6][CH:5]([CH:8]([C:10]2[CH:15]=[CH:14][C:13]([O:16][C:17]([F:20])([F:19])[F:18])=[CH:12][CH:11]=2)[OH:9])[CH2:4][CH2:3]1.BrCC1C=C[C:26]([C:29]2[N:30]=[N:31][N:32]([CH3:34])[N:33]=2)=CC=1.C(N(CC)C(C)C)(C)C>CS(C)=O>[CH3:34][N:32]1[N:31]=[N:30][C:29]([CH2:26][N:2]2[CH2:7][CH2:6][CH:5]([CH:8]([C:10]3[CH:15]=[CH:14][C:13]([O:16][C:17]([F:18])([F:19])[F:20])=[CH:12][CH:11]=3)[OH:9])[CH2:4][CH2:3]2)=[N:33]1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 5893295-(4-Bromomethylphenyl)-2-methyl-2H-tetrazoleHCID 131726693HCID 131726693, compound

Product 1

HCID 68682074HCID 68682074, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

This compound was prepared in a manner analogous to that of Step E of Example 3, using 7.0 grams (0.026 mole) of 4-piperidyl[4-(trifluoromethoxy)phenyl]methanol, hydrochloride, 6.8 grams (0.026 mole) of 5-[4-(bromomethyl)phenyl]-2-methyl-1,2,3,4-tetraazole (prepared in a manner analogous to that of Steps A–C of Example 4), and 9.9 grams (0.077 mole) of N,N-diisopropylethylamine in about 40 mL of DMSO. The NMR spectrum was consistent with the proposed structure.

Workup

  1. customThis compound was prepared in a manner analogous to that of Step E of Example 3

Sources & evidence

ORD record
ord-e4c5c0643bc84807b5ec2b2a41b3ba13
Source dataset
uspto-grants-2007_11
Patent number
US07300946B2

Reaction notes

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