Hydrochloric Acid → HCID 68681623, compound

HRID 1594347Notes

Reaction equation

HRID 1594347 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([CH:7]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)[OH:8])=[CH:3][CH:2]=1.[ClH:19]>C(OCC)(=O)C>[ClH:19].[N:1]1[CH:2]=[CH:3][C:4]([CH:7]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:16])([F:17])[F:18])=[CH:11][CH:10]=2)[OH:8])=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 11694508HCID 11694508, compound

Product 1

HCID 68681623HCID 68681623, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of 21.2 grams (0.070 mole) of 4-pyridyl[4-(trifluoromethyl)phenyl]methanol in 500 mL of ethyl acetate was stirred vigorously and anhydrous hydrogen chloride gas was slowly added during a 15 minute period, below the surface of the solution. The reaction mixture was then stirred for an additional 15 minutes, and a solid was collected by filtration. The solid was washed with ethyl acetate and dried, yielding 11.4 grams of the subject compound. The NMR spectrum was consistent with the proposed structure.

Workup

  1. filtrationa solid was collected by filtration
  2. washThe solid was washed with ethyl acetate
  3. customdried

Sources & evidence

ORD record
ord-04772bacf27d4c6fb85f16a1df8be5c7
Source dataset
uspto-grants-2007_11
Patent number
US07300946B2

Reaction notes

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