Water → HCID 86605569, compound

HRID 1594354Notes

Reaction equation

HRID 1594354 reaction equation
Cl[CH:2]([CH:14]1[CH2:19][CH2:18][N:17]([CH2:20][C:21]2[CH:26]=[CH:25][C:24]([C:27]3[N:28]=[N:29][N:30]([CH2:32][CH3:33])[N:31]=3)=[CH:23][CH:22]=2)[CH2:16][CH2:15]1)[C:3]1[CH:13]=[CH:12][C:6]([O:7][C:8]([F:11])([F:10])[F:9])=[CH:5][CH:4]=1.[F:34][C:35]([F:45])([F:44])[O:36][C:37]1[CH:42]=[CH:41][C:40]([OH:43])=[CH:39][CH:38]=1.C(=O)([O-])[O-].[K+].[K+].O>CN(C=O)C>[CH2:32]([N:30]1[N:29]=[N:28][C:27]([C:24]2[CH:25]=[CH:26][C:21]([CH2:20][N:17]3[CH2:18][CH2:19][C:14](=[C:2]([C:3]4[CH:13]=[CH:12][C:6]([O:7][C:8]([F:11])([F:10])[F:9])=[CH:5][CH:4]=4)[O:43][C:40]4[CH:41]=[CH:42][C:37]([O:36][C:35]([F:34])([F:44])[F:45])=[CH:38][CH:39]=4)[CH2:15][CH2:16]3)=[CH:22][CH:23]=2)=[N:31]1)[CH3:33]

Participants

6

Reactant 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 70015p-(Trifluoromethoxy)phenolHCID 68683931HCID 68683931, compound

Product 1

HCID 86605569HCID 86605569, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of {4-[chloro(1-{[4-(2-ethyl(1,2,3,4-tetraazol-5-yl))phenyl]methyl}(4-piperidyl))methyl]phenoxy}trifluoromethane, 4-(trifluoromethoxy)phenol and potassium carbonate in DMF is stirred at ambient temperature for about two hours. After this time the reaction mixture is poured into water and the mixture is extracted with ethyl acetate. The extract is dried with magnesium sulfate and filtered. The filtrate is concentrated under reduced pressure, yielding compound 137.

Workup

  1. extractionthe mixture is extracted with ethyl acetate
  2. dry with materialThe extract is dried with magnesium sulfate
  3. filtrationfiltered
  4. concentrationThe filtrate is concentrated under reduced pressure

Sources & evidence

ORD record
ord-e2fceb0f53014c9b9e433b2b04a22e65
Source dataset
uspto-grants-2007_11
Patent number
US07300946B2

Reaction notes

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