m-Chloroperbenzoic acid → HCID 69025604, compound

HRID 1594422Notes

Reaction equation

HRID 1594422 reaction equation
[CH:1]12[CH2:7][CH:4]([CH2:5][CH2:6]1)[CH2:3][CH:2]2[C:8]1[S:12][N:11]=[C:10](SC)[N:9]=1.Cl[C:16]1C=C(C=CC=1)C(OO)=O.[S:26]([O-:29])(O)=[O:27].[Na+]>C(Cl)(Cl)Cl>[CH:1]12[CH2:7][CH:4]([CH2:5][CH2:6]1)[CH2:3][CH:2]2[C:8]1[S:12][N:11]=[C:10]([S:26]([CH3:16])(=[O:29])=[O:27])[N:9]=1

Participants

5

Reactant 3

HCID 70297m-Chloroperbenzoic acidHCID 23665763Sodium BisulfiteHCID 58610434HCID 58610434, compound

Product 1

HCID 69025604HCID 69025604, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

1.0 g of 5-(2-norbornyl)-3-methylthio-1,2,4-thiadiazole was dissolved in 9 ml of chloroform, 3.67 g of 3-chloroperoxybenzoic acid (content>65%) was added thereto, and the reaction mixture was stirred for 30 minutes under ice-cooling and for 1 day at room temperature. Then, the reaction mixture was added to saturated sodium hydrogensulfite aqueous solution, and separated. The organic layer was washed with sodium hydrogencarbonate aqueous solution, dried over anhydrous sodium sulfate, concentrated to give 833 mg of 5-(2-norbornyl)-3-methylsulfonyl-1,2,4-thiadiazole.

Workup

  1. customseparated
  2. washThe organic layer was washed with sodium hydrogencarbonate aqueous solution
  3. dry with materialdried over anhydrous sodium sulfate
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-3b60d3b3f6754eec80429e67e79ed3bb
Source dataset
uspto-grants-2007_11
Patent number
US07301032B2

Reaction notes

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