反应详情

500 mg of 5-(2-methylcyclohexyl)-3-methylthio-1,2,4-thiadiazole was dissolved in 6.5 ml of chloroform, 1.62 g of 3-chloroperoxybenzoic acid (content>65%) was added thereto taking for 20 minutes, and the reaction mixture was stirred for 30 minutes under ice-cooling and for 1.5 hours under room temperature. Then, the reaction mixture was added to saturated sodium hydrogensulfite aqueous solution, and separated. The organic layer was washed with sodium hydrogencarbonate aqueous solution, dried over anhydrous sodium sulfate, concentrated to give 466 mg of 3-methylsulfonyl-5-(2-methylcyclohexyl)-1,2,4-thiadiazole.

1. customseparated
2. washThe organic layer was washed with sodium hydrogencarbonate aqueous solution
3. dry with materialdried over anhydrous sodium sulfate
4. concentrationconcentrated