m-Chloroperbenzoic acid → HCID 69027278, compound

HRID 1594425Notes

Reaction equation

HRID 1594425 reaction equation
[CH3:1][CH:2]1[CH2:7][CH2:6][CH:5]([C:8]2[S:12][N:11]=[C:10](SC)[N:9]=2)[CH2:4][CH2:3]1.Cl[C:16]1C=C(C=CC=1)C(OO)=O.[S:26]([O-:29])(O)=[O:27].[Na+]>C(Cl)(Cl)Cl>[CH3:16][S:26]([C:10]1[N:9]=[C:8]([CH:5]2[CH2:6][CH2:7][CH:2]([CH3:1])[CH2:3][CH2:4]2)[S:12][N:11]=1)(=[O:29])=[O:27]

Participants

5

Reactant 3

HCID 70297m-Chloroperbenzoic acidHCID 23665763Sodium BisulfiteHCID 58610432HCID 58610432, compound

Product 1

HCID 69027278HCID 69027278, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

900 mg of 5-(4-methylcyclohexyl)-3-methylthio-1,2,4-thiadiazole was dissolved in 8 ml of chloroform, 2.22 g of 3-chloroperoxybenzoic acid (content>65%) was added thereto taking for 20 minutes, and the reaction mixture was stirred for 4 hours at room temperature. Then, the reaction mixture was added to saturated sodium hydrogensulfite aqueous solution, and separated. The organic layer was washed with sodium hydrogencarbonate aqueous solution, dried over anhydrous sodium sulfate, concentrated to give 1.11 g of 3-methylsulfonyl-5-(4-methylcyclohexyl)-1,2,4-thiadiazole.

Workup

  1. customseparated
  2. washThe organic layer was washed with sodium hydrogencarbonate aqueous solution
  3. dry with materialdried over anhydrous sodium sulfate
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-8d710852c9194e329fd60480143277d9
Source dataset
uspto-grants-2007_11
Patent number
US07301032B2

Reaction notes

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