反应详情

3-Methoxymethyl-3-(3-methoxy-phenyl)-1-methyl-azepan-2-one (as described in Example 6, Step A) (0.391 g, 1.48 mmol) and LiI (0.500 g, 3.73 mol) were heated in collidine (3.5 mL) at 200° C. for 10 h. The reaction mixture was cooled, diluted with EtOAc, washed with 1N HCl (2×), H2O, brine, dried (MgSO4) and concentrated to give the title compound.

1. temperatureThe reaction mixture was cooled
2. washwashed with 1N HCl (2×), H2O, brine
3. dry with materialdried (MgSO4)
4. concentrationconcentrated