反应详情

To a solution of thiocarbonic acid O-[(4-cyano-3-fluoro-phenyl)-pyridin-3-yl-methyl]ester O-phenyl ester (as described in Step A above) (0.5 g, 1.37 mmol) in benzene (2.0 mL) was added AIBN (0.18 g, 1.1 mmol) and tri-n-butyltinhydride (1.09 mL, 4.0 mmol) and the solution was heated to refluxed for 2 hr. The solvents were removed in vacuo to obtain the title compound after chromatography (silica gel, CH2Cl2:MeOH 99:1).

1. temperaturethe solution was heated
2. temperatureto refluxed for 2 hr
3. customThe solvents were removed in vacuo