反应详情

To a solution of 4-[5-(2-amino-ethyl)-2-methyl-imidazol-1-ylmethyl]-2-fluoro-benzonitrile dihydrochloride (as described in Example 34, Step A) (0.3 g, 0.97 mmol) in DMF (5.0 mL) was added NEt3 (0.41 mL, 2.97 mmol) and t-butyl-isocyanate (0.125 mL, 1.07 mmol). After ½ hr the DMF was removed in vacuo and the residue partitioned between EtOAc and saturated NaHCO3. The organic layer was separated, washed with brine and dried (MgSO4). Filtration and concentration in vacuo gave the title compound as an oil.

1. customAfter ½ hr the DMF was removed in vacuo
2. customthe residue partitioned between EtOAc and saturated NaHCO3
3. customThe organic layer was separated
4. washwashed with brine
5. dry with materialdried (MgSO4)
6. filtrationFiltration and concentration in vacuo