Sodium Fluoride → Phenyl Fluoroformate

HRID 1595035Notes

Reaction equation

HRID 1595035 reaction equation
[C:1]1([O:7][C:8](Cl)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[F-:11].[Na+].C1OCCOCCOCCOCCOC1>C(#N)C>[C:1]1([O:7][C:8]([F:11])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 3

HCID 5235Sodium FluorideHCID 15891Phenyl chloroformateHCID 3633615-Crown-5

Product 1

HCID 11815898Phenyl Fluoroformate

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
40 °C

Procedure

To a solution of phenylchloroformate in acetonitrile is charged sodium fluoride. To this mixture is charged the 15-crown-5 (“15C5”) at ambient temperature. The reaction mixture is then heated to 40° C. for approximately 16 hrs. Reaction completion is monitored by gas chromatography (“G.C.”).

Workup

  1. customReaction completion

Sources & evidence

ORD record
ord-8b9ce016ec564ff58f9729c1d8df04f0
Source dataset
uspto-grants-2001_09
Patent number
US06284911B1

Reaction notes

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