反应详情

6-Hydroxy-3-[3-methoxy-4-(1-pyrrolidinylmethyl)benzyl]-2-[4-[4-methoxy-4-oxobutoxy]phenyl]benzo[b]thiophene (147 mg) was dissolved in THF:MeOH:H2O (3:1:1, 3.0 mL), treated with lithium hydroxide monhydrate (12 mg) in one portion, and allowed to stir at ambient temperature for 4 days. The reaction mixture was neutralized with dilute HCl and concentrated in vacuo. The residue was dissolved in methanol. The solution was transfered to a clean vial and solvent was removed with a stream of nitrogen to give the product as an off-white solid. (100 mg).

1. concentrationconcentrated in vacuo
2. dissolutionThe residue was dissolved in methanol
3. customwas removed with a stream of nitrogen