Water → HCID 54424346, compound

HRID 1595103Notes

Reaction equation

HRID 1595103 reaction equation
[C:1]([O:4][C:5](=O)[CH3:6])(=[O:3])[CH3:2].[CH3:8][C:9]1([CH3:21])[C:13]([CH3:14])=[CH:12][CH2:11][CH:10]1[CH:15]=[CH:16][CH2:17]C(O)C.O>CN(C)C1C=CN=CC=1.CC(OC)(C)C>[CH3:8][C:9]1([CH3:21])[C:13]([CH3:14])=[CH:12][CH2:11][CH:10]1[CH:15]=[CH:16][CH2:17][CH:5]([O:4][C:1](=[O:3])[CH3:2])[CH3:6]

Participants

6

Reactant 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 1068064-Penten-2-ol, 5-(2,2,3-trimethyl-3-cyclopenten-1-yl)-

Product 1

HCID 54424346HCID 54424346, compoundYield 95%

Reagents, catalysts & solvents 2

HCID 142844-(Dimethylamino)pyridineCatalystHCID 15413tert-Butyl methyl etherSolvent

Conditions

Temperature
52.5 °C

Procedure

50 g (0.48 mol) of acetic anhydride was added dropwise to the solution of 78.6 g (0.40 mol) of 5-(2,2,3-trimethylcyclopent-3-enyl)pent-4-en-2-ol and 5.0 g of 4-dimethylaminopyridine in 150 ml of MTBE. The reaction mixture was stirred at 50-55° C. for 1 hour, treated with 0.5 l of water and extracted with 3×150 ml of hexane. The combined organic layers were neutralized with aqueous potassium hydrogen carbonate solution, washed with water, dried (MgSO4) and evaporated in vacuo. The residue (102 g) was distilled at 80-81° C./0.2 Torr to give 89.8 g (95% yield) of acetic acid 5-(2,2,3-trimethyl-cyclopent-3-enyl)pent-4-en-2-yl ester.

Workup

  1. extractionextracted with 3×150 ml of hexane
  2. washwashed with water
  3. dry with materialdried (MgSO4)
  4. customevaporated in vacuo
  5. distillationThe residue (102 g) was distilled at 80-81° C./0.2 Torr

Sources & evidence

ORD record
ord-7d307843718246fe8c5d562c3cd56194
Source dataset
uspto-grants-2001_09
Patent number
US06284929B1

Reaction notes

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