Pyridine → HCID 18369538, compound

To an ice-cold solution of 2-bromoacetyl bromide (10.1 g, 50.0 mmol), in CH2Cl2 (200 mL) was added (30 min) a solution of tert-butyl N-{4-(4-aminophenyl)-2-thiazolyl}carbamate (14.6 g, 50.0 mmol, described in example 1) and pyridine (4.04 mL, 50.0 mmol) in CH2Cl2 (50 mL). The reaction mixture was stirred at 0° for 30 min and then at room temperature for 30 min. The reaction mixture then was diluted with in EtOAc (1.5 L). The resulting mixture was washed successively with H2O (500 mL), 10% (w/v) aqueous citric acid (2×500 mL), brine (500 mL), saturated aqueous NaHCO3 (500 mL) and brine (500 mL), then dried (MgSO4) and filtered. The organic solution was concentrated under reduced pressure to a volume of 500 mL. The resulting suspension was filtered and the collected solid was washed with EtOAc (2×10 mL) to yield 13.1 g of the title compound. An additional 2.4 g was obtained by concentration of the filtrate to a volume of 25 mL giving a total of 15.5 g (75% yield) of the tert-butyl N-{4-{4-{(2-bromo-1-oxoethyl)amino}phenyl}-2-thiazolyl}carbamate as a white solid: 1H NMR (400 MHz, DMSO-d6) δ11.54 (s, 1H), 10.44 (s, 1H), 7.82 (d, J=8.7 Hz, 2H), 7.62 (d, J=8.7 Hz, 2H), 7.46 (s, 1H), 4.04 (s, 2H), 1.49 (s, 9H); MS (FAB) m/z412/414 (MH)+.

1. waitat room temperature for 30 min
2. washThe resulting mixture was washed successively with H2O (500 mL), 10% (w/v) aqueous citric acid (2×500 mL), brine (500 mL), saturated aqueous NaHCO3 (500 mL) and brine (500 mL)
3. dry with materialdried (MgSO4)
4. filtrationfiltered
5. concentrationThe organic solution was concentrated under reduced pressure to a volume of 500 mL
6. filtrationThe resulting suspension was filtered
7. washthe collected solid was washed with EtOAc (2×10 mL)

ORD record

ord-d92ffbbe0ef94467af8180b409458595

Source dataset

uspto-grants-2001_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06288091B1