3-Methoxybenzylamine → HCID 178489897, compound

HRID 1595326Notes

Reaction equation

HRID 1595326 reaction equation
O[N:2]=[C:3]([C:11](=O)[C:12]1[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=1)[C:4]([O:6][C:7]([CH3:10])([CH3:9])[CH3:8])=[O:5].[CH3:19][O:20][C:21]1[CH:22]=[C:23]([CH:26]=[CH:27][CH:28]=1)[CH2:24][NH2:25]>C1(C)C=CC=CC=1>[CH3:19][O:20][C:21]1[CH:22]=[C:23]([C:24]2[NH:25][C:11]([C:12]3[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=3)=[C:3]([C:4]([O:6][C:7]([CH3:10])([CH3:9])[CH3:8])=[O:5])[N:2]=2)[CH:26]=[CH:27][CH:28]=1

Participants

4

Reactant 2

HCID 211563-MethoxybenzylamineHCID 178451310HCID 178451310, compound

Product 1

HCID 178489897HCID 178489897, compoundYield 31.2%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

tert-Butyl 2-hydroxyimino-3-oxo-3-(4-pyridyl)propionate (3.2 g) and 3-methoxybenzylamine (2.1 g) were dissolved in toluene (120 ml), and the mixture was reacted and treated in the same manner as in Starting Material Synthetic Example 10 to give tert-butyl 2-(3-methoxyphenyl)-5-(4-pyridyl)imidazole-4-carboxylate (1.4 g), melting point 197-199° C.

Workup

  1. customthe mixture was reacted
  2. additiontreated in the same manner as

Sources & evidence

ORD record
ord-1dcc40747ff943dfbecd29c967fb4815
Source dataset
uspto-grants-2001_09
Patent number
US06288061B1

Reaction notes

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