Stannous Chloride → HCID 178507449, compound

HRID 1595397Notes

Reaction equation

HRID 1595397 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:12][C:11]([C:13]3[CH:18]=[CH:17][C:16]([N+:19]([O-])=O)=[CH:15][CH:14]=3)=[N:10][C:9]=2[C:22]([NH:24][C:25]2[S:26][CH:27]=[CH:28][N:29]=2)=[O:23])=[CH:4][CH:3]=1.[Sn](Cl)Cl>CO.Cl>[NH2:19][C:16]1[CH:17]=[CH:18][C:13]([C:11]2[NH:12][C:8]([C:5]3[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=3)=[C:9]([C:22]([NH:24][C:25]3[S:26][CH:27]=[CH:28][N:29]=3)=[O:23])[N:10]=2)=[CH:14][CH:15]=1

Participants

5

Reactant 2

HCID 24479Stannous ChlorideHCID 178522574HCID 178522574, compound

Product 1

HCID 178507449HCID 178507449, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 887MethanolSolvent

Procedure

5-(4-Fluorophenyl)-2-(4-nitrophenyl)-N-(2-thiazolyl)-imidazole-4-carboxamide obtained in Example 57 is suspended in methanol and ice-cooled. To the suspension is added a solution of tin(II) chloride 6 hydrate in 6 M hydrochloric acid solution and the mixture is reacted and treated in the same manner as in Example 48 to give 2-(4-aminophenyl)-5-(4-fluorophenyl)-N-(2-thiazolyl)-imidazole-4-carboxamide.

Workup

  1. temperatureice-cooled
  2. customthe mixture is reacted
  3. additiontreated in the same manner as in Example 48

Sources & evidence

ORD record
ord-9260ce6d6c87413686d976a2627d42a5
Source dataset
uspto-grants-2001_09
Patent number
US06288061B1

Reaction notes

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