1-Methylpiperazine → HCID 178480817, compound

HRID 1595415Notes

Reaction equation

[Cl:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[NH:13][C:12]([C:14]3[CH:19]=[CH:18][C:17]([N+:20]([O-:22])=[O:21])=[CH:16][CH:15]=3)=[N:11][C:10]=2[C:23]([NH:25][C:26]2[S:27][CH:28]=[CH:29][N:30]=2)=[O:24])=[CH:5][CH:4]=1.[CH3:31][N:32]1[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]1>>[ClH:1].[ClH:1].[ClH:1].[CH3:31][N:32]1[CH2:37][CH2:36][N:35]([CH2:2][C:3]2[CH:8]=[CH:7][C:6]([C:9]3[NH:13][C:12]([C:14]4[CH:19]=[CH:18][C:17]([N+:20]([O-:22])=[O:21])=[CH:16][CH:15]=4)=[N:11][C:10]=3[C:23]([NH:25][C:26]3[S:27][CH:28]=[CH:29][N:30]=3)=[O:24])=[CH:5][CH:4]=2)[CH2:34][CH2:33]1

Participants

Reactant 2

HCID 531671-Methylpiperazine

HCID 178522570HCID 178522570, compound

Product 1

HCID 178480817HCID 178480817, compoundYield 177.5%

Procedure

5-(4-Chloromethylphenyl)-2-(4-nitrophenyl)-N-(2-thiazolyl)-imidazole-4-carboxamide (900 mg) obtained in Example 94 and 1-methylpiperazine (309 mg) were reacted and treated in the same manner as in Example 95 to give 5-(4-(4-methylpiperazin-1-ylmethyl)-phenyl)-2-(4-nitrophenyl)-N-(2-thiazolyl)imidazole-4-carboxamide trihydrochloride (742 mg), melting point 248-252° C. (decomposition).

Workup

additiontreated in the same manner as in Example 95

Sources & evidence

ORD record: ord-27d12b01cc1e4255a733fe8fe2712c7a
Source dataset: uspto-grants-2001_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06288061B1

Reaction notes

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