反应详情

Methyl indole-2-carboxylate (0.15 g) was dissolved in DMF and sodium hydride (41 mg) was added in a single portion. The reaction was stirred for 1 hour, then 3,4-dichlorobenzenesulphonyl chloride (0.25 g) was added in a single portion. Stirring was continued for a further 2 hours and then the reaction was quenched by the addition of water. The reaction mixture was partitioned between water and ethyl acetate. Combined organic extracts were dried (MgSO4) and concentrated in vacuo and the residue purified by column chromatography using isohexane-5% ethyl acetate as eluent to give the desired end product as a solid (51%). NMR δ (CDCl3) 3.96 (s, 3H), 7.22-8.20 (m, 8H); M/z (+) 384 (MH+), 352, 175.

1. stirringStirring
2. waitwas continued for a further 2 hours
3. customthe reaction was quenched by the addition of water
4. customThe reaction mixture was partitioned between water and ethyl acetate
5. dry with materialCombined organic extracts were dried (MgSO4)
6. concentrationconcentrated in vacuo
7. customthe residue purified by column chromatography