2-(2,4-Bis(benzyloxy)phenyl)ethanol → 4-(2-Hydroxyethyl)benzene-1,3-diol

HRID 1595484Notes

Reaction equation

HRID 1595484 reaction equation
C([O:8][C:9]1[CH:14]=[C:13]([O:15]CC2C=CC=CC=2)[CH:12]=[CH:11][C:10]=1[CH2:23][CH2:24][OH:25])C1C=CC=CC=1>C(OCC)(=O)C.[Pd]>[OH:8][C:9]1[CH:14]=[C:13]([OH:15])[CH:12]=[CH:11][C:10]=1[CH2:23][CH2:24][OH:25]

Participants

4

Reactant 1

HCID 148029092-(2,4-Bis(benzyloxy)phenyl)ethanol

Product 1

HCID 134863604-(2-Hydroxyethyl)benzene-1,3-diolYield 99.3%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

3.7 g (11.1 mmole) 2-[2,4-di(benzyloxy)phenyl]-1-ethanol was hydrogenated in 100 ml ethyl acetate using Pd/C (10%) as catalyst. The reaction mixture was filtered and the filtrate was evaporated in vacuo to give 1.7 g (yield 99%) of 2-(2,4-dihydroxyphenyl)-1-ethanol.

Workup

  1. filtrationThe reaction mixture was filtered
  2. customthe filtrate was evaporated in vacuo

Sources & evidence

ORD record
ord-f6ad53db194f46bead28d4ad27118587
Source dataset
uspto-grants-2001_09
Patent number
US06288096B1

Reaction notes

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