反应详情

3.5 g (10.2 mmole) 4-[2-(4-formylphenoxy)ethyl]phenyl N-(tert-butyl)carbamate, 3 g (25.5 mmole) 2,4-thiazolidindione, 0.1 g piperidine and 0.07 g acetic acid in toluene was refluxed with water separation in a Dean-Stark apparatus. The solvent was evaporated in vacuo, acetone and water was added and the formed precipitate was filtered off to give 2 g (yield 45%) of 5-(4-[2-(4-tert-butylaminocarbonyloxyphenyl)ethoxy]benzylidene)thiazolidine-2,4-dione.

1. customThe solvent was evaporated in vacuo, acetone and water
2. additionwas added
3. filtrationthe formed precipitate was filtered off