反应详情

1 g (3.3 mmole) 4-[2-(4-formylphenoxy)ethyl]phenyl methyl sulfone, 0.96 g (8.2 mmole) 2,4-thiazolidinedione, 5 drops of piperidine, 6 drops of acetic acid and toluene were refluxed with water separation in a Dean-Stark apparatus for 1 hour. The heat was removed and the yellow precipitate was filtered off. A slurry of the precipitate and dichloromethane:methanol (95:5) was refluxed. The product was collected by filtration giving 0.9 g (yield 67.6%) of 5-(4-[2-(4-methanesulfonylphenyl)ethoxy]benzylidene)thiazolidine-2,4-dione.

1. customThe heat was removed
2. filtrationthe yellow precipitate was filtered off
3. temperatureA slurry of the precipitate and dichloromethane:methanol (95:5) was refluxed
4. filtrationThe product was collected by filtration