反应详情

温度

135 °C

Using an analogous procedure to that described in Example 157, 196.5 mg (0.5 mmol) of the 7-(2-chloro-ethoxy)-4-(1H-indazol-6-ylamino)-6-methoxy-quinoline-3-carbonitrile, 525.7 mg (5.0 mmol) of diethanolamine and 75.0 mg (0.5 mmol) of sodium iodide in 6 mL of DME was heated at 135° C. for 15 hr. The work up gave 109.1 mg (47.2%) of the product as a yellow solid, m.p. 150° C. (dec.), mass (electrospray, m/e): M+H 463.0.