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HRID1595930

反应详情

EQUATION

反应方程式

HRID 1595930 的结构方程式

REACTANTS

反应物

2
结构：C#CCN
HCID239041

2-Propyn-1-amine

C3H5N

结构：O=C(CCCCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21)NCCCCCC(=O)ON1C(=O)CCC1=O
HCID16219024

N-{6-[(2,5-Dioxopyrrolidin-1-yl)oxy]-6-oxohexyl}-6-({5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}amino)hexanamide

C26H41N5O7S

PRODUCTS

生成物

1
结构：C#CCNC(=O)CCCCCNC(=O)CCCCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21
HCID88234833

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

To a stirred solution of 6-((6-((Biotinoyl)amino)hexanoyl)amino)hexanoic acid, succinimidyl ester (biotin-NHS ester) (0.2 g, 0.35 mmol) in dry DMF (5 ml), propargyl amine (0.04 ml, 0.6 mmol) was added. A white precipitate formed within 15 min and the mixture was stirred overnight. The solvent was removed in vacuo and the compound was dissolved in CHCl3. Next the CHCl3 was slowly added to a stirred solution of hexane, forming a white precipitate, which on drying afforded 0.15 g (83%). Mass Spect. (FAB) MW 508 [M+]; NMR assigned. Crisp, G. T.; Gore, J. Syn. Comm. 1997, 27, 2203-2125

WORKUP

后处理

  1. customA white precipitate formed within 15 min
  2. customThe solvent was removed in vacuo
  3. dissolutionthe compound was dissolved in CHCl3
  4. additionNext the CHCl3 was slowly added to a stirred solution of hexane
  5. customforming a white precipitate, which
  6. customon drying
  7. customafforded 0.15 g (83%)