反应详情

Triphenylphosphine (2.52 g; 9.62 mmol) is added portionwise to a vigorously stirred solution of oleyl alcohol (1.00 g; 3.72 mmol; Fluka, 99%) and tetrabromomethane (1.61 g; 4.84 mmol) in acetonitrile (15 ml) at 0° C. The heterogeneous medium is stirred for 1 h at room temperature. The supernatant is then transferred into a round-bottomed flask and the residual paste is triturated with ether (10 ml) and then filtered. The combined organic solutions are concentrated under reduced pressure to give a colorless oil which is purified by chromatography on a column of silica gel (eluent: hexane) to give oleyl bromide (1.21 g; 98%) in the form of a colorless oil.

1. customThe supernatant is then transferred into a round-bottomed flask
2. customthe residual paste is triturated with ether (10 ml)
3. filtrationfiltered
4. concentrationThe combined organic solutions are concentrated under reduced pressure
5. customto give a colorless oil which
6. customis purified by chromatography on a column of silica gel (eluent: hexane)