3-Pyridinecarboxaldehyde → HCID 131722853, compound

HRID 1596199Notes

Reaction equation

HRID 1596199 reaction equation
[Cl:1][C:2]1[N:3]=[N:4][C:5]([NH:13][NH2:14])=[CH:6][C:7]=1[N:8]1[CH2:12][CH2:11][CH2:10][CH2:9]1.[N:15]1[CH:20]=[CH:19][CH:18]=[C:17](C=O)[CH:16]=1>Cl>[Cl:1][C:2]1[N:3]=[N:4][C:5]([NH:13][N:14]=[C:19]2[CH:18]=[CH:17][CH:16]=[N:15][CH2:20]2)=[CH:6][C:7]=1[N:8]1[CH2:12][CH2:11][CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 103713-PyridinecarboxaldehydeHCID 226099553-Chloro-6-hydrazinyl-4-(1-pyrrolidinyl)pyridazine

Product 1

HCID 131722853HCID 131722853, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

3-Chloro-6-hydrazino-4-(pyrrolidin-1-yl)pyridazine (1.0 g, 4.69 mmol) and 3-pyridinecarboxaldehyde (443 ml, 4.69 mmol) were stirred in 0.2M hydrochloric acid (20 ml) for 2 h. The precipitated imine was then collected by filtration and dried (1.06 g, 75%). MS (ES+) 303 [MH]+, 305 [MH]+.

Workup

  1. filtrationThe precipitated imine was then collected by filtration
  2. customdried (1.06 g, 75%)

Sources & evidence

ORD record
ord-3dd81ce89fb44b79bcc1bb001bed772a
Source dataset
uspto-grants-2001_09
Patent number
US06291460B1

Reaction notes

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