反应详情

HCl-saturated EtOAc (600 mL) was added to a solution of tert-butyl 7-[3-(4-cyanophenoxy)-2-hydroxypropyl]-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate (62 g; see Example 2 below) in EtOAc (600 mL) and the mixture was stirred at rt. for 4 h. The solvent was removed under reduced pressure, the residue was dissolved in MeCN (1.3 L) and K2CO3 (100 g) was added. The suspension was stirred for 12 h and filtered. Concentration of the filtrate gave the title compound in a 90% yield.

1. customThe solvent was removed under reduced pressure
2. dissolutionthe residue was dissolved in MeCN (1.3 L)
3. additionK2CO3 (100 g) was added
4. stirringThe suspension was stirred for 12 h
5. filtrationfiltered