Sulfamide → 1-Methyl-1,3-dihydro-2-thia-1,3-diaza-cyclopenta[B]naphthalene 2,2-dioxide
Reaction equation
[NH2:1][C:2]1[C:11]([NH:12][CH3:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=1.[S:14](N)(N)(=[O:16])=[O:15]>COCCOCCOC>[CH3:13][N:12]1[C:11]2=[CH:10][C:9]3[C:4]([CH:3]=[C:2]2[NH:1][S:14]1(=[O:16])=[O:15])=[CH:5][CH:6]=[CH:7][CH:8]=3Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 160 °C
Procedure
A solution of 2-amino-3-methylamino-naphthalene (168 mg, 0.98 mmol) and sulfamide (44 mg, 0.98 mmol) in anhydrous diglyme (2 mL) was added dropwise over 5 minutes to a flask heated in a 160° C. oil bath. The reaction mixture was heated at 160° C. for an additional 30 minutes, then cooled to room temperature and evaporated under vacuum. The residue was partitioned between ethyl acetate (20 mL) and 2N hydrochloric acid (10 mL). The organic phase was washed with 2N hydrochloric acid (10 mL) and brine (10 mL), dried over magnesium sulfate, and evaporated under vacuum to afford the title compound (160 mg) as a solid.
Workup
- temperatureThe reaction mixture was heated at 160° C. for an additional 30 minutes
- temperaturecooled to room temperature
- customevaporated under vacuum
- customThe residue was partitioned between ethyl acetate (20 mL) and 2N hydrochloric acid (10 mL)
- washThe organic phase was washed with 2N hydrochloric acid (10 mL) and brine (10 mL)
- dry with materialdried over magnesium sulfate
- customevaporated under vacuum
Sources & evidence
- ORD record
- ord-d5fd7940dd4c4e9a9ee6ccfa74240cb9
- Source dataset
- uspto-grants-2001_09
- Patent number
- US06291448B1
Reaction notes
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