Hydrochloric Acid → 8-Methylthiochroman-4-one-7-carboxylic acid o-ethyloxime

HRID 1596764Notes

Reaction equation

[CH2:1]([NH:3]O)[CH3:2].[C:5](=O)([O-])[O-].[K+].[K+].[CH3:11][C:12]1[C:13]([C:23]([OH:25])=[O:24])=[CH:14][CH:15]=[C:16]2[C:21]=1[S:20][CH2:19]CC2=O.Cl.[CH3:27][OH:28]>O>[CH2:27]([O:28][N:3]=[C:1]1[C:16]2[C:21](=[C:12]([CH3:11])[C:13]([C:23]([OH:25])=[O:24])=[CH:14][CH:15]=2)[S:20][CH2:19][CH2:2]1)[CH3:5]

Participants

Conditions

Temperature: 20 °C

Procedure

0.88 g (9 mmol) of ethylhydroxylamine are introduced into 20 ml of methanol. 0.62 g (4.5 mmol) of potassium carbonate are then added. 2.0 g (9 mmol) of 8-methylthiochroman-4-one-7-carboxylic acid are subsequently added. The reaction [sic] is stirred for 10 days at about 20° C. Work-up is carried out by adding water and 2N HCl. The precipitate which forms is filtered off with suction and dried.

Workup

customThe reaction [sic]
filtrationThe precipitate which forms is filtered off with suction
customdried

Sources & evidence

ORD record: ord-7b583803bb0f4fd0bf07a82b15170db2
Source dataset: uspto-grants-2001_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06291682B1

Reaction notes

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