Formaldehyde → HCID 21699073, compound

HRID 1597166Notes

Reaction equation

[CH3:1][S:2][C:3]1[S:8][C:7]2[CH:9]=[CH:10][S:11][C:6]=2[C:5](=[O:12])[CH:4]=1.Cl.CNC.C=O.[C:19](=O)([O-])[O-:20].[K+].[K+]>>[OH:20][CH2:19][C:4]1[C:5](=[O:12])[C:6]2[S:11][CH:10]=[CH:9][C:7]=2[S:8][C:3]=1[S:2][CH3:1]

Participants

Reactant 4

HCID 712Formaldehyde

HCID 10473Dimethylamine, hydrochloride

HCID 11430Potassium Carbonate

HCID 21699033HCID 21699033, compound

Product 1

HCID 21699073HCID 21699073, compoundYield 77%

Procedure

5-Methylthio-7-oxo-7H-thieno-[3,2-b]thiopyran (1.77 g, 8.24 mmol) and dimethylamine hydrochloride (6.05 g, 74.2 mmol), paraformaldehyde (5.29 g) and potassium carbonate (2.28 g) were used to conduct the process similar to that shown in (1) of the Preparation 6, thus obtaining 1.54 g (yield: 77%) of 6-hydroxymethyl-5-methylthio-7-oxo-7H-thieno[3,2-b]thiopyran.

Sources & evidence

ORD record: ord-0e87847c543140029b806734adc01683
Source dataset: uspto-grants-2001_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06294527B1

Reaction notes

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