反应详情

温度

110 °C

1-(2-Chloroethyl)pyrrolidine hydrochloride (1.27 g, 7.5 mmol) was added to 7-hydroxy-6-methoxy-4-phenoxyquinazoline (1.0 g, 3.7 mmol), and potassium carbonate (3.9 g, 28.3 mmol) in DMF (30 ml). The mixture was heated at 110° C. for 4 hours and allowed to cool. The mixture was filtered, and the volatiles were removed from the filtrate by evaporation. The residue was purified by column chromatography eluting with methylene chloride/methanol/ammonia, (100/8/1) to give an oil which was triturated with ethyl acetate to give 6-methoxy-4-phenoxy-7-(2-(pyrrolidin-1-yl)ethoxy)quinazoline (200 mg, 15%) as a white solid.

1. temperatureto cool
2. filtrationThe mixture was filtered
3. customthe volatiles were removed from the filtrate by evaporation
4. customThe residue was purified by column chromatography
5. washeluting with methylene chloride/methanol/ammonia, (100/8/1)
6. customto give an oil which
7. customwas triturated with ethyl acetate