Hydrochloric Acid → 4-Amino-1-benzyl-4-phenylpiperidine dihydrochloride

HRID 1597262Notes

Reaction equation

HRID 1597262 reaction equation
C([NH:4][C:5]1([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH2:10][CH2:9][N:8]([CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:7][CH2:6]1)(=O)C.[ClH:24]>>[ClH:24].[ClH:24].[NH2:4][C:5]1([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH2:10][CH2:9][N:8]([CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:7][CH2:6]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 18964199N-(1-Benzyl-4-phenylpiperidin-4-YL)acetamide

Product 1

HCID 227418004-Amino-1-benzyl-4-phenylpiperidine dihydrochloride

Procedure

The compound prepared in stage B is hydrolyzed by refluxing for 3 hours in 6N HCl. After evaporation to dryness, the residue is dissolved in methanol, crystallized by addition of acetone, filtered and dried to give the expected compound.

Workup

  1. customAfter evaporation to dryness
  2. dissolutionthe residue is dissolved in methanol
  3. customcrystallized by addition of acetone
  4. filtrationfiltered
  5. customdried

Sources & evidence

ORD record
ord-4fc259e5c81e47e6b2e634d060d6d6e0
Source dataset
uspto-grants-2001_09
Patent number
US06294537B1

Reaction notes

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