Hydrochloric Acid → HCID 54547017, compound

HRID 1597651Notes

Reaction equation

HRID 1597651 reaction equation
Cl.C[O:3][C:4](=[O:34])[CH2:5][C@H:6]([NH:13][C:14](=[O:33])[CH2:15][NH:16][C:17](=[O:32])[CH2:18][CH2:19][CH2:20][CH2:21][NH:22][C:23]1[NH:27][C:26]2[CH:28]=[CH:29][CH:30]=[CH:31][C:25]=2[N:24]=1)[C:7]1[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=1>>[NH:24]1[C:25]2[CH:31]=[CH:30][CH:29]=[CH:28][C:26]=2[N:27]=[C:23]1[NH:22][CH2:21][CH2:20][CH2:19][CH2:18][C:17]([NH:16][CH2:15][C:14]([NH:13][C@H:6]([C:7]1[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=1)[CH2:5][C:4]([OH:34])=[O:3])=[O:33])=[O:32]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 59968960HCID 59968960, compound

Product 1

HCID 54547017HCID 54547017, compound

Procedure

A 6N HCl solution (5 ml) of 24-8 (33 mg, 0.073 mmol) was stirred under ambient conditions for 18 hr. The reaction was concentrated to give a viscous gum which was purified by prep HPLC (Delta-Pak C18, gradient elution over 40 min., 5-50% CH3CN/H2O-0.1% TFA) to give 24-9.

Workup

  1. concentrationThe reaction was concentrated
  2. customto give a viscous gum which
  3. customwas purified by prep HPLC (Delta-Pak C18, gradient elution over 40 min., 5-50% CH3CN/H2O-0.1% TFA)
  4. customto give 24-9

Sources & evidence

ORD record
ord-557d6e58f6444df48355344d4739b993
Source dataset
uspto-grants-2001_09
Patent number
US06294549B1

Reaction notes

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