1,1'-Carbonyldiimidazole → HCID 10212480, compound

HRID 1597688Notes

Reaction equation

HRID 1597688 reaction equation
C(N1C=CN=C1)(N1C=CN=C1)=O.[S:13]1[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=2[N:15]=[C:14]1[S:22][CH2:23][C:24]([OH:26])=O.FC(F)(F)C([O-])=O.[NH2:34][C@@H:35]1[C:42](=[O:43])[N:41]2[C@@H:36]1[S:37][CH2:38][C:39](/[CH:47]=[C:48]1/[C:49](=[O:71])[N:50]([CH2:53][C:54]3[CH:59]=[CH:58][N+:57]([CH2:60][C:61](=[O:70])[NH:62][C:63]4[CH:68]=[CH:67][C:66]([OH:69])=[CH:65][CH:64]=4)=[CH:56][CH:55]=3)[CH2:51][CH2:52]/1)=[C:40]2[C:44]([OH:46])=[O:45]>CN(C)C(=O)C>[OH:69][C:66]1[CH:65]=[CH:64][C:63]([NH:62][C:61]([CH2:60][N+:57]2[CH:58]=[CH:59][C:54]([CH2:53][N:50]3[CH2:51][CH2:52]/[C:48](=[CH:47]\[C:39]4[CH2:38][S:37][C@H:36]5[N:41]([C:42](=[O:43])[C@H:35]5[NH:34][C:24](=[O:26])[CH2:23][S:22][C:14]5[S:13][C:17]6[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=6[N:15]=5)[C:40]=4[C:44]([O-:46])=[O:45])/[C:49]3=[O:71])=[CH:55][CH:56]=2)=[O:70])=[CH:68][CH:67]=1

Participants

5

Reactant 3

HCID 682631,1'-CarbonyldiimidazoleHCID 805252-(2-Benzothiazolylthio)acetic acidHCID 86757436HCID 86757436, compound

Product 1

HCID 10212480HCID 10212480, compound

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

With 70.0 mg (0.43 mmol) 1,1′-carbonyldiimidazole, 96.0 mg (0.43 mmol) (benzothiazol-2-ylsulfanyl)-acetic acid and 233.8 mg (0.36 mmol) (E)-(6R,7R)-7-amino-3-[1-[1-[(4-hydroxy-phenylcarbamoyl)-methyl]-pyridin-1-ium-4-ylmethyl]-2-oxo-pyrrolidin-3-ylidenemethyl]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate trifluoroacetate in 4 ml N,N-dimethylacetamide.

Sources & evidence

ORD record
ord-fb8276d41ee34768833a8baded6ababd
Source dataset
uspto-grants-2001_09
Patent number
US06294668B1

Reaction notes

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