HRID1597689

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID68263

1,1'-Carbonylbis(1H-imidazole)

C7H6N4O

HCID80525

2-(Carboxymethylthio)benzothiazole

C9H7NO2S2

$结构：N[C@@H]1C(=O)N2C(C(=O)O)=C(/C=C3\CCN(CC4CC4)C3=O)CS[C@H]12$

HCID10689147

未命名化合物

PRODUCTS

生成物

$结构：O=C(CSc1nc2ccccc2s1)N[C@@H]1C(=O)N2C(C(=O)O)=C(/C=C3\CCN(CC4CC4)C3=O)CS[C@H]12$

HCID15405982

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

With 220.0 mg (1.35 mmol) 1,1′-carbonyldiimidazole, 304.1 mg (1.35 mmol) (benzothiazol-2-ylsulfanyl)-acetic acid and 394.8 mg (1.13 mmol) (E)-(6R,7R)-7-amino-3-(1-cyclopropylmethyl-2-oxo-pyrrolidin-3-ylidenemethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid in 7 ml N,N-dimethylformamide.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-786e37033cdc423887e37cad3164ab0f
来源数据集: uspto-grants-2001_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06294668B1
来源说明: uspto-grants-2001_09

反应 SMILES

C(N1C=CN=C1)(N1C=CN=C1)=O.[S:13]1[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=2[N:15]=[C:14]1[S:22][CH2:23][C:24]([OH:26])=O.[NH2:27][C@@H:28]1[C:35](=[O:36])[N:34]2[C@@H:29]1[S:30][CH2:31][C:32](/[CH:40]=[C:41]1/[C:42](=[O:50])[N:43]([CH2:46][CH:47]3[CH2:49][CH2:48]3)[CH2:44][CH2:45]/1)=[C:33]2[C:37]([OH:39])=[O:38]>CN(C)C=O>[S:13]1[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=2[N:15]=[C:14]1[S:22][CH2:23][C:24]([NH:27][C@@H:28]1[C:35](=[O:36])[N:34]2[C@@H:29]1[S:30][CH2:31][C:32](/[CH:40]=[C:41]1/[C:42](=[O:50])[N:43]([CH2:46][CH:47]3[CH2:49][CH2:48]3)[CH2:44][CH2:45]/1)=[C:33]2[C:37]([OH:39])=[O:38])=[O:26]