HRID1597692

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID66728

Acetic acid, (2-naphthalenylthio)-

C12H10O2S

HCID68263

1,1'-Carbonylbis(1H-imidazole)

C7H6N4O

$结构：N[C@@H]1C(=O)N2C(C(=O)O)=C(/C=C3\CCN(CC4CC4)C3=O)CS[C@H]12$

HCID10689147

未命名化合物

PRODUCTS

生成物

$结构：O=C(CSc1ccc2ccccc2c1)N[C@@H]1C(=O)N2C(C(=O)O)=C(/C=C3\CCN(CC4CC4)C3=O)CS[C@H]12$

HCID69468177

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

With 167.0 mg (1.03 mmol) 1,1′-carbonyldiimidazole, 225.0 mg (1.03 mmol (naphthalen-2-ylsulfanyl)-acetic acid and 300.0 mg (0.86 mmol) (E)-(6R,7R)-7-amino-3-(1-cyclopropylmethyl-2-oxo-pyrrolidin-3-ylidenemethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid in 4 ml N,N-dimethylformamide.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1ca65c6d97224bed8a540b673bbe5fda
来源数据集: uspto-grants-2001_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06294668B1
来源说明: uspto-grants-2001_09

反应 SMILES

C(N1C=CN=C1)(N1C=CN=C1)=O.[CH:13]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]=[CH:15][C:14]=1[S:23][CH2:24][C:25]([OH:27])=O.[NH2:28][C@@H:29]1[C:36](=[O:37])[N:35]2[C@@H:30]1[S:31][CH2:32][C:33](/[CH:41]=[C:42]1/[C:43](=[O:51])[N:44]([CH2:47][CH:48]3[CH2:50][CH2:49]3)[CH2:45][CH2:46]/1)=[C:34]2[C:38]([OH:40])=[O:39]>CN(C)C=O>[CH:48]1([CH2:47][N:44]2[CH2:45][CH2:46]/[C:42](=[CH:41]\[C:33]3[CH2:32][S:31][C@H:30]4[N:35]([C:36](=[O:37])[C@H:29]4[NH:28][C:25](=[O:27])[CH2:24][S:23][C:14]4[CH:15]=[CH:16][C:17]5[C:22](=[CH:21][CH:20]=[CH:19][CH:18]=5)[CH:13]=4)[C:34]=3[C:38]([OH:40])=[O:39])/[C:43]2=[O:51])[CH2:50][CH2:49]1