Indoline → HCID 9879615, compound

HRID 1597922Notes

Reaction equation

HRID 1597922 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.Cl[C:11]1[C:20]2[C:15](=[CH:16][C:17]([O:23][CH3:24])=[C:18]([O:21][CH3:22])[CH:19]=2)[N:14]=[CH:13][N:12]=1>CC(O)C>[N:1]1([C:11]2[C:20]3[C:15](=[CH:16][C:17]([O:23][CH3:24])=[C:18]([O:21][CH3:22])[CH:19]=3)[N:14]=[CH:13][N:12]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 10328IndolineHCID 27693644-Chloro-6,7-dimethoxyquinazoline

Product 1

HCID 9879615HCID 9879615, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Utilizing a procedure analogous to that described in Example 2, this product was prepared in 94% yield from indoline (2 eq.) and 4-chloro-6,7-dimethoxyquinazoline (1.0 eq) in i-PrOH. (M.P. 162°-163° C.; LC-MS: 308 (MH+); anal. RP18-HPLC RT: 4.11 min.).

Sources & evidence

ORD record
ord-861b9d9059274d9f946ec0948cb60e61
Source dataset
uspto-grants-1998_04
Patent number
US05736534

Reaction notes

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