1,2,3,4-Tetrahydroquinoline → HCID 18770805, compound

HRID 1597925Notes

Reaction equation

HRID 1597925 reaction equation
[NH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1.Cl[C:12]1[C:21]2[C:16](=[CH:17][C:18]([O:24][CH3:25])=[C:19]([O:22][CH3:23])[CH:20]=2)[N:15]=[CH:14][N:13]=1>CC(O)C>[N:1]1([C:12]2[C:21]3[C:16](=[CH:17][C:18]([O:24][CH3:25])=[C:19]([O:22][CH3:23])[CH:20]=3)[N:15]=[CH:14][N:13]=2)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 694601,2,3,4-TetrahydroquinolineHCID 27693644-Chloro-6,7-dimethoxyquinazoline

Product 1

HCID 18770805HCID 18770805, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Utilizing a procedure analogous to that described in Example 2, this product was prepared in 91% yield from 1,2,3,4-tetrahydroquinoline (2 eq.) and 4-chloro-6,7-dimethoxy-quinazoline (1.0 eq) in i-PrOH. (M.P. 130°-131° C.; LC-MS: 322 (MH+); anal. RP18-HPLC RT: 4.08 min.).

Sources & evidence

ORD record
ord-2fcc71a4386d49da92fdc0362d2b733d
Source dataset
uspto-grants-1998_04
Patent number
US05736534

Reaction notes

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