6-Methyl-1,2,3,4-tetrahydroquinoline → HCID 18932846, compound

HRID 1597926Notes

Reaction equation

HRID 1597926 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH2:7][CH2:6][CH2:5]2.Cl[C:13]1[C:22]2[C:17](=[CH:18][C:19]([O:25][CH3:26])=[C:20]([O:23][CH3:24])[CH:21]=2)[N:16]=[CH:15][N:14]=1>CC(O)C>[CH3:24][O:23][C:20]1[CH:21]=[C:22]2[C:17](=[CH:18][C:19]=1[O:25][CH3:26])[N:16]=[CH:15][N:14]=[C:13]2[N:8]1[C:9]2[C:4](=[CH:3][C:2]([CH3:1])=[CH:11][CH:10]=2)[CH2:5][CH2:6][CH2:7]1

Participants

4

Reactant 2

HCID 666786-Methyl-1,2,3,4-tetrahydroquinolineHCID 27693644-Chloro-6,7-dimethoxyquinazoline

Product 1

HCID 18932846HCID 18932846, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Utilizing a procedure analogous to that described in Example 2, this product was prepared in 94% yield from 6-methyl-1,2,3,4-tetrahydroquinoline (2 eq.) and 4-chloro-6,7-dimethoxy-quinazoline (1.0 eq) in i-PrOH. (M.P. 147°-148° C.; LC-MS: 336 (MH+); anal. RP18-HPLC RT: 4.51 min.).

Sources & evidence

ORD record
ord-97dff889a47f4932980fa92dba59c955
Source dataset
uspto-grants-1998_04
Patent number
US05736534

Reaction notes

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