4-Chloro-6,7-dimethoxyquinazoline → HCID 18932793, compound

HRID 1597942Notes

Reaction equation

HRID 1597942 reaction equation
[OH:1][CH2:2][CH:3]1[CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[NH:4]1.Cl[C:13]1[C:22]2[C:17](=[CH:18][C:19]([O:25][CH3:26])=[C:20]([O:23][CH3:24])[CH:21]=2)[N:16]=[CH:15][N:14]=1>CC(O)C>[CH3:24][O:23][C:20]1[CH:21]=[C:22]2[C:17](=[CH:18][C:19]=1[O:25][CH3:26])[N:16]=[CH:15][N:14]=[C:13]2[N:4]1[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH2:11][CH:3]1[CH2:2][OH:1]

Participants

4

Reactant 2

HCID 27693644-Chloro-6,7-dimethoxyquinazolineHCID 27946642,3-dihydro-1H-indol-2-ylmethanol

Product 1

HCID 18932793HCID 18932793, compoundYield 57%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Utilizing a procedure analogous to that described in Example 1, this product was prepared in 57% yield from 2-hydroxymethyl-indoline (1 eq.) and 4-chloro-6,7-dimethoxy-quinazoline (1.0 eq) in i-PrOH. (M.P. 145.5°-147° C.; LC-MS: 338 (MH+); anal. RP18-HPLC RT: 4.03 min.).

Sources & evidence

ORD record
ord-02b274695d154e58830826f0869097ec
Source dataset
uspto-grants-1998_04
Patent number
US05736534

Reaction notes

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