4-Chloro-6,7-dimethoxyquinazoline → HCID 18932776, compound

HRID 1597946Notes

Reaction equation

HRID 1597946 reaction equation
[O:1]1[C:5]2=[CH:6][C:7]3[CH2:8][CH2:9][NH:10][C:11]=3[CH:12]=[C:4]2[O:3][CH2:2]1.Cl[C:14]1[C:23]2[C:18](=[CH:19][C:20]([O:26][CH3:27])=[C:21]([O:24][CH3:25])[CH:22]=2)[N:17]=[CH:16][N:15]=1>CC(O)C>[CH3:25][O:24][C:21]1[CH:22]=[C:23]2[C:18](=[CH:19][C:20]=1[O:26][CH3:27])[N:17]=[CH:16][N:15]=[C:14]2[N:10]1[C:11]2[CH:12]=[C:4]3[O:3][CH2:2][O:1][C:5]3=[CH:6][C:7]=2[CH2:8][CH2:9]1

Participants

4

Reactant 2

HCID 27693644-Chloro-6,7-dimethoxyquinazolineHCID 12369276HCID 12369276, compound

Product 1

HCID 18932776HCID 18932776, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Utilizing a procedure analogous to that described in Example 1, this product was prepared in 93% yield from 6,7-dihydro-5H-[1,3]dioxolo[4,5-f]indole (1.1 eq.), and 4-chloro-6,7-dimethoxy-quinazoline (1.0 eq) in i-PrOH. (M.P. 225°-228° C. (dec); LC-MS: 352 (MH+); anal. RP18-HPLC RT: 3.91 min.).

Sources & evidence

ORD record
ord-8f30caa16e0e4e83aab49145607115bb
Source dataset
uspto-grants-1998_04
Patent number
US05736534

Reaction notes

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