4-Chloro-6,7-dimethoxyquinazoline → HCID 18932858, compound

HRID 1597947Notes

Reaction equation

HRID 1597947 reaction equation
[CH:1]([C:4]1[CH:12]=[C:11]2[C:7]([CH2:8][CH2:9][NH:10]2)=[CH:6][CH:5]=1)([CH3:3])[CH3:2].Cl[C:14]1[C:23]2[C:18](=[CH:19][C:20]([O:26][CH3:27])=[C:21]([O:24][CH3:25])[CH:22]=2)[N:17]=[CH:16][N:15]=1>CC(O)C>[CH:1]([C:4]1[CH:12]=[C:11]2[C:7]([CH2:8][CH2:9][N:10]2[C:14]2[C:23]3[C:18](=[CH:19][C:20]([O:26][CH3:27])=[C:21]([O:24][CH3:25])[CH:22]=3)[N:17]=[CH:16][N:15]=2)=[CH:6][CH:5]=1)([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 27693644-Chloro-6,7-dimethoxyquinazolineHCID 14344794HCID 14344794, compound

Product 1

HCID 18932858HCID 18932858, compoundYield 43%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Utilizing a procedure analogous to that described in Example 1, this product was prepared in 43% yield from 6-isopropyl-indoline (1.1 eq.), and 4-chloro-6,7-dimethoxy-quinazoline (1.0 eq) in i-PrOH. (M.P. 128°-129° C.; LC-MS: 350 (MH+); anal. RP18-HPLC RT: 5.51 min.).

Sources & evidence

ORD record
ord-f92ec11c9ab6468192bda3085fb526d2
Source dataset
uspto-grants-1998_04
Patent number
US05736534

Reaction notes

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