4-Chloro-6,7-dimethoxyquinazoline → HCID 18932755, compound

HRID 1597950Notes

Reaction equation

HRID 1597950 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][C:6]([NH:10][CH:11]([CH3:18])[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.Cl[C:20]1[C:29]2[C:24](=[CH:25][C:26]([O:32][CH3:33])=[C:27]([O:30][CH3:31])[CH:28]=2)[N:23]=[CH:22][N:21]=1>CC(O)C>[CH3:31][O:30][C:27]1[CH:28]=[C:29]2[C:24](=[CH:25][C:26]=1[O:32][CH3:33])[N:23]=[CH:22][N:21]=[C:20]2[N:1]1[C:9]2[C:4](=[CH:5][C:6]([NH:10][CH:11]([CH3:18])[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])=[CH:7][CH:8]=2)[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 27693644-Chloro-6,7-dimethoxyquinazolineHCID 18932780HCID 18932780, compound

Product 1

HCID 18932755HCID 18932755, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Utilizing a procedure analogous to that described in Example 1, this product was prepared in 96% yield from [2,3-dihydro-1H-indol-5-yl]-(1-methyl-heptyl)-amine (1.1 eq.), and 4-chloro-6,7-dimethoxy-quinazoline (1.0 eq) in i-PrOH. (M.P. 61°-63° C.; GC-MS: 434 (M+); anal. RP18-HPLC RT: 6.91 min.).

Sources & evidence

ORD record
ord-2e570cc2b1bd4566a3c7a0d4410f1c58
Source dataset
uspto-grants-1998_04
Patent number
US05736534

Reaction notes

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