Hydrochloric Acid → HCID 18932778, compound

HRID 1597954Notes

Reaction equation

HRID 1597954 reaction equation
Cl.[OH:2][C:3]1[CH:4]=[C:5]2[C:9](=[C:10]([CH3:13])[C:11]=1[CH3:12])[NH:8][CH2:7][CH2:6]2.[Cl:14][C:15]1[C:24]2[C:19](=[CH:20][C:21]([O:27][CH3:28])=[C:22]([O:25][CH3:26])[CH:23]=2)[N:18]=[CH:17][N:16]=1>CN1CCCC1=O>[ClH:14].[CH3:26][O:25][C:22]1[CH:23]=[C:24]2[C:19](=[CH:20][C:21]=1[O:27][CH3:28])[N:18]=[CH:17][N:16]=[C:15]2[N:8]1[C:9]2[C:5](=[CH:4][C:3]([OH:2])=[C:11]([CH3:12])[C:10]=2[CH3:13])[CH2:6][CH2:7]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 27693644-Chloro-6,7-dimethoxyquinazolineHCID 22238082HCID 22238082, compound

Product 1

HCID 18932778HCID 18932778, compoundYield 40%

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

Utilizing a procedure analogous to that described in Example 47 this product (with conversion to the HCl salt as outlined for Example 2) was prepared in 40% yield from 5-hydroxy-6,7-dimethyl-indoline (1.1 eq.), and 4-chloro-6,7-dimethoxy-quinazoline (1.0 eq) in N-methyl-pyrrolidinone. (M.P. 207°-209° C. (dec); LC-MS: 352 (MH+); anal. RP18-HPLC RT: 3.48 min.).

Sources & evidence

ORD record
ord-76eda310336e43d8905b481af44f8246
Source dataset
uspto-grants-1998_04
Patent number
US05736534

Reaction notes

Loading…