Pyridine → HCID 18932865, compound

HRID 1597993Notes

Reaction equation

HRID 1597993 reaction equation
Cl.Cl[C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([N:13]3[CH2:18][CH2:17][N:16]([CH3:19])[CH2:15][CH2:14]3)[CH:11]=2)[N:6]=[CH:5][N:4]=1.[Cl:20][C:21]1[CH:29]=[C:28]2[C:24]([CH2:25][CH2:26][NH:27]2)=[CH:23][CH:22]=1.N1C=CC=CC=1>ClCCCl>[Cl:20][C:21]1[CH:29]=[C:28]2[C:24]([CH2:25][CH2:26][N:27]2[C:3]2[C:12]3[C:7](=[CH:8][CH:9]=[C:10]([N:13]4[CH2:18][CH2:17][N:16]([CH3:19])[CH2:15][CH2:14]4)[CH:11]=3)[N:6]=[CH:5][N:4]=2)=[CH:23][CH:22]=1

Participants

5

Reactant 3

HCID 1049PyridineHCID 2585676-Chloro-2,3-dihydro-1h-indoleHCID 18932829HCID 18932829, compound

Product 1

HCID 18932865HCID 18932865, compound

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

4-Chloro-6-(4-methylpiperazin-1-yl)-quinazoline hydrochloride (537 mg, 1.80 mmol) and 6-chloroindoline (169 mg, 1.10 mmol) were refluxed in 10 mL of 1,2-dichloroethane and pyridine (350 mg, 4.40 mmol) for 48 hours. The product was isolated as the (58%); using the analogous method of Example 120; 267 mg (58%); M.P. 289°-290° C.

Workup

  1. customThe product was isolated as the (58%)

Sources & evidence

ORD record
ord-c12375d8737a4a35ac2068a81083ae6a
Source dataset
uspto-grants-1998_04
Patent number
US05736534

Reaction notes

Loading…