Hydrochloric Acid → HCID 18932743, compound

HRID 1597994Notes

Reaction equation

HRID 1597994 reaction equation
Cl.[F:2][C:3]1[C:11]([CH3:12])=[C:10]2[C:6]([CH2:7][CH2:8][NH:9]2)=[CH:5][CH:4]=1.[Cl:13][C:14]1[C:23]2[C:18](=[CH:19][C:20]([O:26][CH3:27])=[C:21]([O:24][CH3:25])[CH:22]=2)[N:17]=[CH:16][N:15]=1>CN1CCCC1=O>[ClH:13].[F:2][C:3]1[C:11]([CH3:12])=[C:10]2[C:6]([CH2:7][CH2:8][N:9]2[C:14]2[C:23]3[C:18](=[CH:19][C:20]([O:26][CH3:27])=[C:21]([O:24][CH3:25])[CH:22]=3)[N:17]=[CH:16][N:15]=2)=[CH:5][CH:4]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 27693644-Chloro-6,7-dimethoxyquinazolineHCID 189327666-Fluoro-7-methylindoline

Product 1

HCID 18932743HCID 18932743, compoundYield 58%

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

Utilizing a procedure analogous to that described in Example 47 (with conversion to the HCl salt analogous to Example 2), this product was prepared in 58% yield from 6-fluoro-7-methyl-indoline (1.1 eq.), and 4-chloro-6,7-dimethoxy-quinazoline (1.0 eq) in N-methyl-pyrrolidinone. (M.P. 220°-225° C.; LC-MS: 340 (MH+); anal. RP18-HPLC RT: 4.63 min.).

Sources & evidence

ORD record
ord-456683129dc34a1da3ef49b669d6077e
Source dataset
uspto-grants-1998_04
Patent number
US05736534

Reaction notes

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