反应详情

Utilizing a procedure analogous to that described in Example 47 (with conversion to the HCl salt analogous to Example 2), this product was prepared in 58% yield from 6-fluoro-7-methyl-indoline (1.1 eq.), and 4-chloro-6,7-dimethoxy-quinazoline (1.0 eq) in N-methyl-pyrrolidinone. (M.P. 220°-225° C.; LC-MS: 340 (MH+); anal. RP18-HPLC RT: 4.63 min.).