4-Chloro-6,7-dimethoxyquinazoline → HCID 18932772, compound

HRID 1597995Notes

Reaction equation

HRID 1597995 reaction equation
[CH3:1][Si:2]([C:5]#[C:6][C:7]1[CH:15]=[C:14]2[C:10]([CH2:11][CH2:12][NH:13]2)=[CH:9][CH:8]=1)([CH3:4])[CH3:3].Cl[C:17]1[C:26]2[C:21](=[CH:22][C:23]([O:29][CH3:30])=[C:24]([O:27][CH3:28])[CH:25]=2)[N:20]=[CH:19][N:18]=1>CN1CCCC1=O>[CH3:28][O:27][C:24]1[CH:25]=[C:26]2[C:21](=[CH:22][C:23]=1[O:29][CH3:30])[N:20]=[CH:19][N:18]=[C:17]2[N:13]1[C:14]2[C:10](=[CH:9][CH:8]=[C:7]([C:6]#[C:5][Si:2]([CH3:3])([CH3:4])[CH3:1])[CH:15]=2)[CH2:11][CH2:12]1

Participants

4

Reactant 2

HCID 27693644-Chloro-6,7-dimethoxyquinazolineHCID 18932749HCID 18932749, compound

Product 1

HCID 18932772HCID 18932772, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

Utilizing a procedure analogous to that described in Example 47, this product was prepared in 93% yield from 6-trimethylsilanylethynyl-indoline (1.1 eq.), and 4-chloro-6,7-dimethoxy-quinazoline (1.0 eq) in N-methyl-pyrrolidinone. (LC-MS: 404 (MH+); anal. RP18-HPLC RT: 6.49 min.).

Sources & evidence

ORD record
ord-06ccb60163434e1b8aa3eceb4d4874a4
Source dataset
uspto-grants-1998_04
Patent number
US05736534

Reaction notes

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