Hydrochloric Acid → HCID 18932796, compound

HRID 1597999Notes

Reaction equation

HRID 1597999 reaction equation
Cl.[CH3:2][N:3]([CH2:5][CH2:6][CH2:7][CH:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[NH:10][CH2:9]1)[CH3:4].Cl[C:18]1[C:27]2[C:22](=[CH:23][C:24]([O:30][CH3:31])=[C:25]([O:28][CH3:29])[CH:26]=2)[N:21]=[CH:20][N:19]=1>CN(C=O)C>[CH3:29][O:28][C:25]1[CH:26]=[C:27]2[C:22](=[CH:23][C:24]=1[O:30][CH3:31])[N:21]=[CH:20][N:19]=[C:18]2[N:10]1[C:11]2[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:8]([CH2:7][CH2:6][CH2:5][N:3]([CH3:4])[CH3:2])[CH2:9]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 27693644-Chloro-6,7-dimethoxyquinazolineHCID 54476869HCID 54476869, compound

Product 1

HCID 18932796HCID 18932796, compoundYield 52%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Utilizing a procedure analogous to that described in Example 24 (with conversion to its HCl salt using a procedure analogous to that as described in Example 2), this product was prepared in 52% yield from 3-(N,N-dimethylamino-propyl)indoline (1.1 eq.), and 4-chloro-6,7-dimethoxy-quinazoline (1.0 eq) in DMF. (M.P. 230°-232° C.; LC-MS: 393 (MH+); anal. RP18-HPLC RT: 3.23 min.).

Sources & evidence

ORD record
ord-1f5d005ee44b4964a0f3bcee4c45f3dd
Source dataset
uspto-grants-1998_04
Patent number
US05736534

Reaction notes

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