Trifluoroacetic acid → HCID 67672704, compound

HRID 1598020Notes

Reaction equation

HRID 1598020 reaction equation
[C@H:1]1([NH2:8])[CH2:6][CH2:5][CH2:4][C@H:3]([NH2:7])[CH2:2]1.[F:9][C:10]([F:15])([F:14])[C:11]([OH:13])=[O:12]>>[F:9][C:10]([F:15])([F:14])[C:11]([OH:13])=[O:12].[C@H:1]1([NH2:8])[CH2:6][CH2:5][CH2:4][C@H:3]([NH2:7])[CH2:2]1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 6999482HCID 6999482, compound

Product 1

HCID 67672704HCID 67672704, compound

Procedure

±-trans-Cyclohexane-1,3-diamine: 22.9 g of the BOC derivative are introduced into 1 00 ml of trifluoroacetic acid while cooling with ice. The mixture is left at RT for 4 hours, evaporated and the residue is recrystallized from 200 ml of acetonitrite. 8.5 g of ±-trans-cyclohexane-1,3-diamine trifluoroacetate, m.p. 200° C. (sintering) are obtained.

Workup

  1. temperaturewhile cooling with ice
  2. customevaporated
  3. customthe residue is recrystallized from 200 ml of acetonitrite

Sources & evidence

ORD record
ord-ffc6130b383646acb455c97c1240bde5
Source dataset
uspto-grants-1998_04
Patent number
US05736557

Reaction notes

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