2-(Methylamino)ethanol → HCID 18933632, compound

HRID 1598320Notes

Reaction equation

HRID 1598320 reaction equation
Br[CH2:2][C:3]1[CH:10]=[CH:9][C:6]([C:7]#[N:8])=[CH:5][CH:4]=1.[CH3:11][NH:12][CH2:13][CH2:14][OH:15]>C1(C)C(C)=CC=CC=1>[OH:15][CH2:14][CH2:13][N:12]([CH2:2][C:3]1[CH:10]=[CH:9][C:6]([C:7]#[N:8])=[CH:5][CH:4]=1)[CH3:11]

Participants

4

Reactant 2

HCID 80162-(Methylamino)ethanolHCID 869964-(Bromomethyl)benzonitrile

Product 1

HCID 18933632HCID 18933632, compound

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

A mixture of 4-bromomethylbenzonitrile (49.7 g), N-methylethanolamine (19.0 g) and xylene (100 ml) was boiled under reflux with stirring for 7 hours and then worked up as described in the previous example to give an oil which was distilled at 142°-146° C. at 0.5 mbar to give 4-[N-(2-hydroxyethyl)-N-methylaminomethyl]benzonitrile as an oil.

Workup

  1. temperatureunder reflux
  2. customto give an oil which
  3. distillationwas distilled at 142°-146° C. at 0.5 mbar

Sources & evidence

ORD record
ord-67abdbe1a5564650af00fe17c32c608c
Source dataset
uspto-grants-1998_04
Patent number
US05736568

Reaction notes

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