Sodium Sulfite → HCID 18929406, compound

HRID 1598528Notes

Reaction equation

HRID 1598528 reaction equation
ClC1C=C(C(F)(F)F)C=C(Cl)C=1C1N(C)N=C(SC)C=1.[Cl:21][C:22]1[CH:27]=[C:26]([C:28]([F:31])([F:30])[F:29])[CH:25]=[C:24]([Cl:32])[C:23]=1[C:33]1[N:37]([CH3:38])[N:36]=[C:35]([S:39]([CH3:41])=[O:40])[CH:34]=1.ClC1C=CC=C(C(OO)=[O:50])C=1.S([O-])([O-])=O.[Na+].[Na+]>C(Cl)(Cl)Cl>[Cl:32][C:24]1[CH:25]=[C:26]([C:28]([F:31])([F:29])[F:30])[CH:27]=[C:22]([Cl:21])[C:23]=1[C:33]1[N:37]([CH3:38])[N:36]=[C:35]([S:39]([CH3:41])(=[O:50])=[O:40])[CH:34]=1

Participants

6

Reactant 4

HCID 24437Sodium SulfiteHCID 70297m-Chloroperbenzoic acidHCID 18929398HCID 18929398, compoundHCID 18929415HCID 18929415, compound

Product 1

HCID 18929406HCID 18929406, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To a solution of 0.2 g of 5-(2,6-dichloro-4-trifluoromethylphenyl)-1-methyl-3-methylsulfenylpyrazole (compound 40) in 20 ml of anhydrous chloroform was slowly added 0.3 g of 70% m-chloroperbenzoic acid at room temperature, followed by stirring overnight. The reaction mixture was poured into 10% aqueous sodium sulfite solution, and the organic layer was separated off, washed with 5% aqueous sodium hydroxide solution and brine and dried over anhydrous magnesium sulfate. The solvent was thereafter distilled of under reduced pressure to give 0.3 g of the desired compound in the form of white crystals (quantitative crude yield).

Workup

  1. customat room temperature
  2. customthe organic layer was separated off
  3. washwashed with 5% aqueous sodium hydroxide solution and brine
  4. dry with materialdried over anhydrous magnesium sulfate
  5. distillationThe solvent was thereafter distilled of under reduced pressure

Sources & evidence

ORD record
ord-a90f52b05a9c4d55b97883831885ae9d
Source dataset
uspto-grants-1998_04
Patent number
US05739083

Reaction notes

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