反应详情

In 55 ml of water were dissolved 2.45 g of 2-n-butylsulfonylamino-5-[4,5-dihydropyridazin-3(2H)-on-6-yl]indane and 1.40 g of sodium hydroxide, and 2.66 g of sodium 3-nitrobenzenesulfonate was added thereto. The mixture was refluxed under heating for 5 hours. After cooling, the reaction mixture was made acidic with 10% hydrochloric acid and extracted with ethyl acetate, the extract was dried, and then the solvent was removed. The resulting crystals were recrystallized from methanol to obtain 1.62 g of 2-n-butylsulfonylamino-5-[pyridazin-3(2H)-on-6-yl]-indane.

1. additionwas added
2. temperatureThe mixture was refluxed
3. temperatureunder heating for 5 hours
4. temperatureAfter cooling
5. extractionextracted with ethyl acetate
6. customthe extract was dried
7. customthe solvent was removed
8. customThe resulting crystals were recrystallized from methanol